ANM
2010
3rd
International Conference on Advanced Nano Materials
12-15 September 2010 - Agadir, Morocco
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Abstract
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ANMM194 |
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THERMOSENSITIVE HYDROGELS INCORPORATING GOLD NANOSTRUCTURES
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A.L. Daniel-da-Silva, J. Moreira, R. Neto, A.M. Gil, T. Trindade |
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CICECO - Chemistry Dept., University of Aveiro, 3810-193 Aveiro, Portugal |
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At
present time, clinicians deal with the need of novel therapeutic
systems incorporating several functions on one platform, such as
targeting, imaging and therapy, in order to provide an early disease
diagnosis and simultaneous monitoring and treatment, as a response to
the corresponding therapy. One promising route for preparing these
platforms includes the synthesis of nanocomposites which
synergistically combine the properties of the individual components
with improved final features.
This work was focused on the synthesis and characterization of
bionanocomposites comprising a naturally occurring polymeric matrix
with thermoreversible properties (carrageenan hydrogel) and gold
nanoparticles (Au NPs) as a dispersed phase. Hydrogels are commonly
used as drug carriers, and Au NPs have found application in optical
clinical imaging and new bio-applications are in perspective since gold
nanostructures have found to emit intense heat upon adequate optical
stimuli. Here an integrated characterization approach, comprising
thermal, rheological and vibrational spectroscopy measurements, was
carried out to investigate the effect of incorporating Au NPs into the
hydrogel matrix. The modulated release of a soluble drug trapped in the
bionanocomposites was induced by thermal and optical stimuli and has
been studied using UV-Vis spectroscopy.
The nanocomposites developed in the way described above will combine
the optical properties arising from Au NPs, as well as the
thermosensitivity and hydrophilicity from hydrogels, making them
promising candidates for novel platforms implying diagnostic and
therapeutic abilities for various biomedical applications.
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