ANM
2010
3rd
International Conference on Advanced Nano Materials
12-15 September 2010 - Agadir, Morocco
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Abstract
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ANMM103 |
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SYNTHESIS OF HIGH CONCENTRATION COLLOID SOLUTION OF SILICA-COATED AGI NANOPARTICLES |
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Yoshio KOBAYASHI, Marie MINATO, Kazuaki IHARA, Tomohiko NAKAGAWA, Kohsuke GONDA, Motohiro TAKEDA, Noriaki OHUCHI, Atsuo KASUYA |
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Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University, Hitachi, Ibaraki 316-8511, Japan
Division of Surgical Oncology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8575, Japan
Center for Interdisciplinary Research, Tohoku University, Sendai, Miyagi 980-8578, Japan |
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We
have studied on preparation of silica-coated AgI (AgI/SiO2)
nanoparticles toward new X-ray contrast agents. The
preparation method is composed of preparation of AgI nanoparticles and
silica-coating them. Colloid solution of the AgI particles
was prepared by mixing AgClO4 aqueous solution and KI aqueous solution,
and silica-coating was performed by adding
3-mercaptopropyltrimethoxysilane, tetraethylorthosilicate/ethanol
solution and NaOH to the AgI colloid solution. In our
recent works, AgI/SiO2 particles could be prepared at an AgI
concentration of 10-3 M, which was, however, still low compared with
that of the commercial contrast agent. The aim of the
present work is to examine various methods for synthesizing high
concentration AgI/SiO2 particle colloid that reveals X-ray contrast
property as well as the commercial X-ray contrast agent
does. The first was a single step-method, which was to
perform our previous method for preparing AgI/SiO2 particle colloid at
an AgI concentration of not 10-3 but 5×10-3 M. The
second was a multiple step-method, which was to repeat a step for our
previous method 5 times for adjusting a final AgI concentration to
5×10-3 M. In the two methods, dominant particle
aggregation took place, though core-shell particles were also
produced. The third was a salting out-method, which was to
salt out AgI/SiO2 particles in their colloid solution prepared at an
AgI concentration of 10-3 M, remove supernatant by decantation, and
redisperse the particles in saline. AgI/SiO2 particles with
an AgI concentration as high as 0.05 M were successfully prepared with
the salting out-method, and their core-shell structure was not damaged
during the salting-out.
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